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KMID : 0941820070170020130
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Korean Journal of Clinical Pharmacy
2007 Volume.17 No. 2 p.130 ~ p.137
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Placebo-Controlled Intervention Study for the Efficacy and Safety of Block and Burn in the Mild Obesity Patient
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Choe Soo-Young
Lee Chong-Kil
Jung Yeun-Bok
Song Suk-Gil
Kim Nam-Sik
Lee Myung-Koo
Cho Byung-Suk
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Abstract
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The purpose of the present study was to evaluate the efficacy and safety of Block and burn®, a 4:1 mixture of Phaseolus vulgaris and Garcinia cambogia extracts, in reducing body weight, as the main outcome measure. Secondary measures of the study were body composition change in overweight human subjects. A randomized, double-blinded, placebocontrolled study was conducted on 52 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least 2 weeks, The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product (1.2 g) containing Phaseolus vulgaris (200 mg) and Garcinia cambogia (50 mg) and the placebo (1.2 g) were taken 6 tablets per day for 56 consecutive days, respectively. Each subject’s body weight, body mass index (BMI), body fat, body fat ratio, and waist hip ratio (WHR) were measured. After 56 days (8 weeks), subjects receiving Block and burn ® had significantly greater reduction of body weight. Moreover, a significant changes of the BMI, body fat, and body fat ratio were observed in the test group compared to placebo. However, WHR was not statistically different between groups. These results indicated that Block and burn® produced significant decrements in body weight and suggested decrements in fat mass in the face of maintained lean body mass.
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KEYWORD
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Block and burn, Phaseolus vulgaris extract, Garcinia cambogia extract, Body weight, Body mass index
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